Bence-Jones protein - quantitativeDefinition:
This test measures the level of abnormal proteins called Bence-Jones proteins in the urine.
Immunoglobulin light chains - urine; Urine Bence-Jones protein
How the Test is Performed:
A clean-catch urine sample is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, the health care provider may give you a special clean-catch kit that contains a cleansing solution and sterile wipes. Follow instructions exactly so that the results are accurate.
How the Test will Feel:
The test involves only normal urination, and there is no discomfort.
Why the Test is Performed:
Bence-Jones proteins are a part of regular antibodies called light chains. These proteins are not normally in urine. Sometimes, when your body makes too many antibodies, the level of light chains also rises. Bence-Jones proteins are small enough to be filtered out by the kidneys. Then they spill over into the urine.
Your doctor may order this test:
- To diagnose health conditions that lead to protein in the urine
- If you have a lot of protein in your urine
- If you have signs of multiple myeloma
Urine immunofixation is a better test for detecting Bence-Jones proteins.
A normal result means no Bence-Jones proteins are found in your urine.
What Abnormal Results Mean:
Bence-Jones proteins are rarely found in urine. If they are, it is usually associated with multiple myeloma .
An abnormal result may also be due to:
McPherson RA, Ben-Ezra J. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 28.