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Platelet associated antibodies

Definition

How the Test is Performed

A sample of blood will be taken from your vein.

How to Prepare for the Test

How the Test will Feel

Why the Test is Performed

Normal Results

A negative test is normal.

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

What Abnormal Results Mean

Abnormal results show that you have antiplatelet antibodies. These are proteins made by your body that attach to platelets and destroy them. This causes a low platelet count, which can lead to excessive bleeding.

Antiplatelet antibodies may appear in the blood for unknown reasons (idiopathic thrombocytopenic purpura or ITP). It can also be a side effect of certain drugs such as gold, heparin, quinidine, and quinine. These drugs can sometimes cause the immune system to attack its own platelets as foreign.

Risks

:

  • Excessive bleeding
  • Fainting or feeling light-headed
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)

Considerations

Current tests cannot tell for sure whether a low platelet count (thrombocytopenia) is caused by immune problems. Therefore, your doctor will make a diagnosis based on other tests and examinations.

This test is often performed because you have a bleeding problem. Bleeding may be more of a risk for you than for people who do not have bleeding problems.

References

Nichols WL. Von Willebrand disease and hemorrhagic disorders: Abnormalities of platelet and vascular function. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 176.

Warlemtom TE. Thrombocytopenia due to platelet destruction and hypersplenism. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Saunders Elsevier; 2012:chap 134.


Review Date: 3/3/2013
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.
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