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Glanzmann's disease

Definition

Glanzmann's disease is a rare disorder of blood platelets, which results in easy bruising and nosebleeds.

Alternative Names

Thrombasthenia

Causes

Symptoms

  • Bleeding during and after surgery
  • Bleeding gums
  • Easy bruising
  • Heavy menstrual bleeding
  • Nosebleeds (epistaxis)
  • Prolonged bleeding with minor injuries

Exams and Tests

The following tests may be used to diagnose this condition:

Other tests may be needed, including the testing of relatives.

Treatment

There is no specific treatment for this disorder. Platelet transfusions may be given to patients who are having severe bleeding.

Outlook (Prognosis)

Possible Complications

When to Contact a Medical Professional

Call your health care provider if:

  • You have bleeding or bruising of an unknown cause
  • Bleeding does not stop after usual treatments

Prevention

References

Macartney CA, Paredes N, Chan AKC. Disorders of Coagulation in the Neonate. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Saunders Elsevier; 2012:chap 152.

Nichols WL.Von Willebrand Disease and Hemorrhagic Abnormalities of Platelet and Vascular Function. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 176.


Review Date: 3/3/2013
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.
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